Endocrine Abstracts

Objective: Graves’ Disease (GD) is one of the most common autoimmune disorders. Some SNP in pro-inflammatory cytokines have already been linked to an increased susceptibility of developing GD. Thyroid hormones are crucial modulators of lipid metabolism. A pro-inflammatory state, may contribute several metabolic changes, including disturbances in lipid metabolism. Our aim was to evaluate if SNP in pro-inflammatory cytokines also contribute to disturbances of lipid profile ...

Introduction: The malignancy of the thyroglossal duct cyst is infrequent, 0.7 to 1% of the thyroglossal duct cysts, predominantly in women and euthyroid subjects, some associated with Hashimoto’s Thyroiditis. Clinical case: Male, 42 years old, with a 5-year history of a large anterior cervical tumor, diagnosed with Graves’ disease and thyroid orbitopathy. Cervical ultrasound reports right submandibular region mixed tumor mass 36 x30. mm with no...

Introduction: Anomalies of glucose metabolism and insulin resistance are common in patients with hypothyroidism. Some studies suggests that euthyroid autoimmune thyroiditis (AIT) may also be associated with changes of glucose metabolism and insulin resistance. The role of thyroid hormones resistance in this context is still uncertain.Aim: To evaluate the relationship between thyroid hormones resistance, insulin resistance and lipid profile in euthyroid p...

Introduction: Morbid obesity is a highly prevalent disease, with bariatric surgery being a fundamental pillar in its treatment.Objectives: To analyze the results of weight loss at 5 years in patients operated by gastric bypass and sleeve at the Regional University Hospital of Malaga.Methods: This is a retrospective observational study, where 104 patients with morbid obesity who underwent bariatric surgery at the Regional University...

Introduction: Pituitary apoplexy describes the ischemic or hemorrhagic phenomenon that occurs in a previous pituitary adenoma. It may be the first manifestation of a pituitary gland adenoma.Case 1: Female 31 years old macroprolactinoma in irregular treatment with cabergoline for three months Amenorrhea from the age of 14. Decreased visual acuity and oppressive headache. MRI pituitary apoplexy. Hospitalized and discharged with cabergoline and prednisone. ...

Background: Cardiac fibrosis is a common biological response to cardiovascular injury. Maladaptive cardiac fibrosis as observed in patients with hypertension, obesity or diabetes mellitus contributes to contractile dysfunction and electrophysiological disorders. Currently, there is controversy regarding whetherexposure to a high fat diet (HFD) in isolation induces cardiovascular damage and fibrosis. Here, we set out to explore the contribution of different models of obesity to...

Background: Pituitary tumours (PT) are generally benign, but they can rarely show an aggressive behaviour, invade surrounding structures and/or grow/recur despite multimodal treatment, making their management extremely challenging. According to the latest guidelines, temozolomide (TMZ) can be an option after failure of standard therapies in aggressive PT, while little data are available on alternative approaches such as peptide receptor radionuclide therapy (PRRT). Herein we r...

Introduction: People living with human immunodeficiency virus (HIV) are at increased risk of developing metabolic disorders, such as obesity, dyslipidemia, insulin resistance, diabetes and hypertension; which may also be associated with hypercortisolism. Due to the similarity between the metabolic changes present in these two clinical situations, several studies have evaluated whether HIV-infected patients have increased levels of cortisol, but the results are not consensual. ...

Different animal models have been used to study the postnatal effect of a prenatal exposure to an androgen excess on the female offspring. We have established a sheep model to test the hypothesis that the intrauterine environment of the PCOS mother may play a role in the etiology of the PCOS. In this regard, our sheep model for the study of PCOS has the advantage that provides mainly an androgenized milieu to the fetus in comparison to pregnant PCOS women who offers a hyperand...

Introduction: Pheochromocytoma is one of the major secondary causes of hypertension. The classic triad of pheochromocytoma symptoms of headache, sweating and tachycardia is not present in a high percentage of patients and is sometimes diagnosed as incidentaloma or atypical presentations.Case report: The authors present a 56-year-old man, with no known diseases, referred to Endocrinology evaluation by incidentaloma of the right adrenal gland, from the Pne...